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Dr. Mariam Martin: 5 Years Bootstrapping Deep Tech Alone, From Lab Bench to Space

AirLabOne founder Dr. Mariam Martin on 5 years bootstrapping deep tech without co-founders, winning a global patent across 3 jurisdictions, and technology built for microgravity and space.

by hao-nguyen on February 25, 2026

About the guest

Dr. Mariam Martin-Mnatsakanyan

Founder and CEO at AirLabOne

Dr. Mariam Martin is the founder and CEO of AirLabOne, an Australian deep tech startup building embedded technology to make legacy industrial and scientific machinery self-regulating and autonomous. A trained analytical chemist, she completed postdoctoral research at the University of Geneva and the University of Sydney, where her frustration with accessing physical lab equipment sparked the idea for AirLabOne. She has spent five years bootstrapping the business alone, securing patents in Australia, the US, and Europe, and winning validation at the Select USA Investor Summit before expanding toward Southern California and raising her first external capital.

Episode overview

Dr. Mariam Martin joins Steve Grace to talk about one of the least common founder stories in the Australian startup ecosystem: five years of building a deep tech hardware company entirely alone, without co-founders, without external funding, and without compromising the original vision based on advice from people who did not understand the technology. AirLabOne is now ready to pilot, holds five granted patents, and is preparing to expand to Southern California.

Making old machinery think for itself

AirLabOne’s core technology takes existing “dumb” legacy machinery in industries like healthcare, mining, and space research, and makes it intelligent and self-regulating. The problem this solves is most acute in environments that are harsh, isolated, or otherwise hostile to human presence. In microgravity, in underground mines, and in remote locations, machines need to be able to self-manage. AirLabOne’s embedded technology creates that autonomy. “Physical AI,” which other startups are now using as a category description, is something AirLabOne had patents around years before the term became common.

“If it was easy, if it was openly accessible, available, every second person would do it. It comes down to 5% of population or even less. They do the big change.”

Dr. Mariam Martin on what it takes to be a deep tech founder 01:00

Five years alone and why that was the right call

Mariam spent the first three years exploring technology applications, filing patents, and trying to follow investor advice that kept pulling the business in the wrong direction. Investors told her not to go into edtech. She went into health tech. That back-and-forth cost years. The turning point came when she stopped taking advice from people outside her specific domain and committed to her own structured plan. The last two years produced the real progress: product pilot readiness, international patent grants, and external validation at the Select USA Investor Summit in Washington. Steve’s observation is direct: “You ignored the investors, good.”

Research resilience as a founder advantage

Mariam attributes her ability to persist through five years of solo bootstrapping to her research background. Drug discovery is fundamentally a process of failing, learning, and going again. “When we say five years, it’s not like five years working on the same product. The first two three years I was kind of finding technology applications.” That willingness to fail systematically without losing confidence comes from training that most business founders have never had. The progression from failure to proof feels natural to a researcher. To most first-time founders, it feels like dying.

“I had my own structure how to progress this without listening. Everyone was saying everyone has ideas. So at the end of the day, you have to have your way of progressing and just do have a plan and execute.”

Dr. Mariam Martin on ignoring outside advice 13:00

Key takeaways

Five years alone is not unusual for deep tech, it is necessary.Hardware and deep tech timelines are fundamentally different from SaaS. The first few years are often patent-seeking and technology validation before any commercial traction is possible.
Taking advice from outside your domain wastes years.Mariam spent three years following investor advice that pointed her toward market categories that did not fit her technology. The breakthrough came when she stopped and trusted her own structured plan.
Patents in three jurisdictions are a genuine competitive moat.Holding granted patents in Australia, the US, and Europe for a genuinely novel technology means AirLabOne is the only player licensed to operate in that space in all three major markets simultaneously.
Research training builds a form of resilience that startup culture cannot teach.Drug discovery requires iterating through failure systematically for years. That tolerance for failed experiments without losing faith in the overall direction is rare in the startup world and extremely valuable.
Physical AI as a category was real before it was named.AirLabOne had patents in the physical AI space before the term became a startup category descriptor. Being early in a category that the market catches up to is a powerful strategic position.
Progress, not certainty, sustains resilience over the long term.Mariam describes each small step forward as the fuel that powers the next step. The feeling of movement, even incremental movement, is what makes five years of solo bootstrapping psychologically survivable.

Mentioned in this episode

Frequently asked questions

What is AirLabOne and what does it do?

AirLabOne is an Australian deep tech startup that makes embedded technology to digitise assets in complex and critical industries including healthcare, mining, and space. The technology makes existing legacy machinery intelligent and self-regulating, able to operate autonomously in environments where human intervention is impossible, such as microgravity or underground mining. AirLabOne holds patents in Australia, the US, and Europe for its remote access technology.

How did Dr. Mariam Martin bootstrap AirLabOne for 5 years?

Dr. Mariam Martin bootstrapped AirLabOne for five years without traditional funding or co-founders, relying on her research background and a structured approach to progress. The first three years involved invention, patent-seeking, and exploring technology applications. The real commercial progress came in the final two years once she stopped following investor advice that did not fit her technology and committed to her own plan.

What patents does AirLabOne hold?

AirLabOne holds approximately five granted patents covering its technology for remotely accessing real and virtual scientific instruments. The patents have been granted in Australia, the United States, and Europe, demonstrating genuine novelty across all three major markets. The company also maintains a patent strategy with provisional patents to protect ongoing innovation.

Why is AirLabOne expanding to Southern California?

Southern California is a hub for aerospace and space technology companies, and AirLabOne’s technology for autonomous operation in microgravity environments positions it to work with the companies clustered there. The expansion follows validation at the Select USA Investor Summit in Washington and is part of a broader strategy to raise external capital and pilot the technology with international customers.

What is physical AI and why is AirLabOne ahead in this space?

Physical AI refers to artificial intelligence applied to physical assets and environments rather than purely digital systems. AirLabOne had patents in this space before physical AI became a recognised startup category. Dr. Martin now sees many new startups describing themselves as physical AI companies, which she views as validation that the category she was building toward years ago has arrived.

Topics discussed

Deep TechBootstrappingSolo FounderPhysical AISpace TechHardware StartupsPatentsAustralian Startups

Full transcript

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Show full transcript (37 minutes, 5 sections)

00:00 Introduction and business overview

Steve introduces Mariam as one of the most scientifically impressive founders he has met in the startup ecosystem. Mariam describes AirLabOne as building embedded technology to digitise assets for complex industries, creating autonomy for machinery in healthcare, space, and mining. The business is part of a broader transition from physical to digital world and a response to the global shortage of human resources in safety-critical industries.

04:53 Microgravity and the space application

Mariam explains that microgravity, the near-zero gravity environment in space, creates conditions where cells behave differently than they do on Earth. Drug discovery experiments that cannot be conducted under terrestrial conditions need to happen in space. AirLabOne’s technology for making physical assets self-regulating applies directly to scientific instruments that need to operate autonomously on space missions, including the adaptation of existing Earth-based laboratory equipment for use in low gravity environments.

13:03 Five years of solo bootstrapping

Mariam describes the emotional reality of five years without co-founders, without funding, and working from a university innovation centre desk. The loneliness was real. What sustained her was progress: completing one step, seeing it work, and using that as energy for the next. She traces the evolution of her thinking on outside advice: early on she followed investor direction toward edtech and health tech, which wasted years. The breakthrough came when she trusted her own structured plan regardless of external pressure.

19:00 Select USA validation and expansion

AirLabOne won validation at the Select USA Investor Summit in Washington, which opened doors to the US market and provided independent confirmation that the technology was addressing a real and significant problem. Mariam is now preparing to expand to Southern California, where the concentration of aerospace and space technology companies aligns with AirLabOne’s most compelling applications. A major space grant is pending that could fund local manufacturing in clean rooms.

29:56 Sustainability and the old infrastructure opportunity

A core insight of AirLabOne is that the most sustainable approach to industrial digitalisation is not replacing old equipment but making it smarter. The planet cannot afford to throw away functional industrial machinery simply because it lacks digital intelligence. AirLabOne’s technology pairs with existing infrastructure, extending its useful life while adding the autonomy that modern operations require. This is both the pitch and the environmental case for the approach.

About the host

Steve Grace is the CEO and co-founder of The Nudge Group, a talent and advisory firm working with Australia’s fastest-growing tech and professional services companies. He has spent two decades recruiting and advising executive teams. Give It A Nudge is where he shares unfiltered conversations with founders, operators, and investors building something worth talking about. Connect on LinkedIn.

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